National Vulvodynia Association

Participants Needed for a Study on Vestibulodynia (Pain at the opening of the vagina with touch, sexual contact and/or tampon use).

For more information please contact Safia Kahn or Haley Cutting at:
obgynresearch@mednet.ucla.edu
(310) 794-3467

If you are a female 18-50 years of age who has had at least 3 continuous months of pain at the vaginal opening with touch, tampon use, and/or sexual contact, you may be eligible to participate in this study. This study is open for enrollment at UCLA Westwood Medical Plaza and will remain open for 1.5 more years. Study involvement includes 4 study visits over a six month time period. Participants are given free medication, free parking and compensation for their time.

https://sites.duke.edu/updatestudy/

Vulvodynia Pain Thresholds

For more information, please contact Vanessa Barnabei, MD,Phd by phone 716-881-7564 or email vmbarnab@buffalo.edu

Ages Eligible for Study: 18 Years to 50 Years (Adult)
Sexes Eligible for Study: Female
Gender Based Eligibility: Yes
Gender Eligibility Description: Vulvodynia is a sex-specific disorder. Only women will be enrolled.
Accepts Healthy Volunteers: Yes
Sampling Method: Probability Sample

https://clinicaltrials.gov/ct2/show/study/NCT04461210?cond=vulvodynia&draw=2&rank=3

A Necessary Multi-Parametric Evaluation of Vulvodynia

If you are interested in taking part in this study, please go to the following page http://www.med.unc.edu/ppru/research and click on the “Registry” link at the bottom of the page.

Women between the ages of 21 and 75 who have been diagnosed by their doctor with vulvodynia and/or experience pain in the vaginal region upon contact (ie. tampon use, intercourse, or pelvic exam) or without contact, for at least 3 months, may be eligible to participate in this study.

The research study involves undergoing sensory testing, a modified gynecological exam and will require 3 visits to the University of North Carolina. Participants will receive up to $200 for complete participation. The purpose of this study is to get a better understanding of a chronic pain syndrome called vulvodynia, or pain in the vulvar (pelvic) region.

http://www.med.unc.edu/ppru/research/current-research-1/a-necessary-multi-parametric-evaluation-of-vulvodynia

Participants Needed for a Study on Vestibulodynia (Pain at the opening of the vagina with touch, sexual contact and/or tampon use).

To find out if you are eligible or if you want more information, please contact Debbie Farb at:
debbie.farb@unc.edu
(919) 886 – 3024

If you are a female 18-50 years of age who has had at least 3 continuous months of pain at the vaginal opening with touch, tampon use, and/or sexual contact, you may be eligible to participate in this study. This study is open for enrollment at UNC Hospitals, Hillsborough Campus, and will remain open for 4 more years. Study involvement includes 4 study visits over a six month time period. Participants are given free medication, and compensation for their time.

https://sites.duke.edu/updatestudy/

A Prospective Longitudinal Data Bank Creation to Study Vaginal Conditions With a Novel Diagnostic Approach

For more information please contact Jennifer R Hinojosa, RN, by phone 432-335-5113  or email  jennifer.hinojosa@ttuhsc.edu  

The purpose of this study is to identify and elucidate the pattern and perhaps role of atypical proteins, cytokines and vaginal microbial flora in the pathogenic mechanisms involved in the development of vulvodynia, recurrent fungal and bacterial vaginosis and preterm labor.


Eligibility
Ages Eligible for Study:  
21 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:  
Female
Accepts Healthy Volunteers:  
Yes


Sampling Method:  
Non-Probability Sample


Study Population
All patients willing to participate, and give informed consent, and Asymptomatic, non-pregnant, healthy women ages 21 to 75 years with no previous history of any chronic or recurrent vulvovaginal condition who attend our clinical offices for their annual well-woman physical examination.
2—Non-pregnant women ages 21 to 75 years being evaluated for any gynecological vulvovaginal condition.
Pregnant women ages 21 to 75 years who are both asymptomatic and healthy Pregnant women ages 21 to 75 who have any gynecological vulvovaginal condition


Criteria
Inclusion Criteria:
All patients willing to participate, and give informed consent, and
Asymptomatic, non-pregnant, healthy women ages 21 to 75 years with no previous history of any chronic or recurrent vulvovaginal condition who attend our clinical offices for their annual well-woman physical examination.
Non-pregnant women ages 21 to 75 years being evaluated for any gynecological vulvovaginal condition.
Pregnant women ages 21 to 75 years who are both asymptomatic and healthy
Pregnant women ages 21 to 75 who have any gynecological vulvovaginal condition
Exclusion Criteria:
Asymptomatic patients ages < 21 or > 75, or symptomatic patients ages < 21 or > 75 years.
Patients diagnosed with cancer or having any medical condition that is not under control including: diabetes mellitus, hypertension, collagen disease, hemoglobinopathy, renal insufficiency, depression, anxiety, psychosis and panic attacks
Patients unable to follow the protocol or unwilling to participate

https://clinicaltrials.gov/ct2/show/NCT01829204?term=vulvodynia&rank=34

Effect of Two Acupuncture Protocols on Vulvodynia (Acu/Vul-pain)

For more information, or if you are interested in participating in this study, please contact Arthur Y Fan, MD (CHN), PhD by phone 703-499-4428 or email ArthurFan@ChineseMedicineDoctor.us

You may be eligible to participate in this study if you are a women between the ages of 18 and 45, have been diagnosed with generalized and/or provoked vestibulodynia by an OB/GYN or pain specialist and have a current pain score higher than 4 with tampon insertion and removal, or cotton swab test at the initial screen test. Participants must be able to speak and read either English or Chinese.

This study evaluates acupuncture for the treatment of vulvodynia; specifically, if it reduces vulvar pain, pain duration and pain with intercourse. It also examines how long the effect of acupuncture lasts in women with vulvodynia. One-third of the women will receive acupuncture focused on pudendal nerve distribution area; another one-third of the women will receive acupuncture focused on traditional meridian points; the other one-third of women will receive standard care (without acupuncture). Women who experience a reduction in pain (included in subjective and objective scores) will have their pain monitored once a week for up to 6 weeks to see if the acupuncture effect lasts.

Exclusion Criteria:

1. infectious conditions of the vulva/vagina;
2. inflammatory conditions of the vulva/vagina;
3. neoplastic disorders of the vulva/vagina;
4. neurologic disorders of the vulva/vagina;
5. acute trauma to the genitals;
6. iatrogenic conditions of the genitals
7. hormonal deficiencies
8. co-morbid pelvic pain conditions (to avoid confounding pain outcomes) such as pelvic inflammatory disease and documented history of endometriosis
9. menopause
10. patients who have active migraine headaches, temporomandibular joint disease (TMJ), irritable bowel syndrome (IBS), interstitial cystitis, painful bladder syndrome, or fibromyalgia, in past 6 month.

https://clinicaltrials.gov/ct2/show/study/NCT03481621#contacts

Persons with Vaginas who have Genito-Pelvic Pain and the Role it Plays in their Intimate Relationships with other Persons with Vaginas.

For additional information or if you are interested in participating, please contact Lindsey Fisher by email lfisher31@capellauniversity.edu or phone 480-788-1029 (text or call).

Do you have a vaginal genito-pelvic pain condition, like vulvodynia or vaginismus? Are you currently or have you been in an intimate relationship with a person with a vagina in the last 3 years?

Lindsey Fisher is conducting research for her doctoral dissertation on persons with vaginas who have genito-pelvic pain and the role it plays in their intimate relationships with other persons with vaginas.

Seeking participants for study who meet these qualifications:
• Between 21-50 years old
• Presence of a genito-pelvic pain (GPP) condition
• Experienced GPP at least 4 times in the last year
• Experienced GPP at least once in the last 2 months
• Your GPP has affected your relationship(s)
• Have been in at least one intimate relationship with a person with a vagina in the last 3 years
• Have not experienced menopause
• Have ability to participate via Zoom video call

* Lindsey’s intent is to be as inclusionary as possible. The key population she is seeking includes queer women, non-binary, assigned female at birth, and trans persons with a vagina with a vaginal pain condition who are in a relationship with another person with a vagina.

Exclusions:
• Pain that can be attributed to a non-sexual, diagnosed medical condition, e.g., fibromyalgia.
• Persons who are experiencing or have had menopause.
• Outside of the age range of 21-50 years of age.
• Persons who have pain conditions, but it does not affect your relationship(s)

Study procedures: interview via Zoom
Time commitment required: 1 interview, approximately 1 hour; possible 2nd interview for follow-up and clarification, time may vary.

https://lindseyafisher.wixsite.com/research

Pelvic Floor Myofascia: A New Player Involved in Vulvodynia

For more information or to participate please contact Camille Simard, M.Sc. by phone 819-821-8000 ext 18439 or email labomorin@usherbrooke.ca
OR
Contact Mélanie Morin, P.T., Ph.D. by phone 819-821-8000 ext 13818 or email melanie.m.morin@usherbrooke.ca

Study Population:
Asymptomatic controls (without any vulvar pain) and women suffering from provoked vestibylodynia (moderate to severe pain for at least 90% of the time when engaging in or attempting sexual intercourse) are being recruited.

Inclusion Criteria:

No pain during sexual intercourse (for the healthy women)
Moderate to severe pain (≥ 5/10) during sexual intercourse for at least 3 months (for women with provoked vestibulodynia)
Moderate to severe pain (≥ 5/10) at least 90% of the time when engaging in or attempting sexual intercourse for at least 3 months (for women with provoked vestibulodynia)

Exclusion Criteria:

Current or past pregnancy
Urogynecological condition (e.g., pelvic organ prolapse stage ≥ 3, urinary leakage, current urinary/vaginal infection or in the last 3 months)
Other causes of vulvo-vaginal pain (e.g., spontaneous vulvovaginal pain not related to sexual intercourse/contact, dermatological condition, herpes, vulvo-vaginal atrophy)
Post-menopausal state
Previous vulvar, vaginal or pelvic surgery (e.g., vestibulectomy, pelvic organ prolapse surgery)
Prior use of pelvic floor physiotherapy
Medication that could influence pain perception (e.g., analgesic, antidepressant)
Other medical conditions that could interfere with the study

https://clinicaltrials.gov/ct2/show/NCT05350618?cond=vulvodynia&draw=2&rank=31

Laser Therapy for Vulvodynia (Lydia)

For more information, please contact Gerda Trutnovsky, MD by phone +43 316 385 ext 81081 or email gerda.trutnovsky@medunigraz.at
or
contact Karl Tamussino, MD by phone +43 316 385 ext 81068 or email karl.tamussino@medunigraz.at

Ages Eligible for Study: 18 Years to 80 Years (Adult, Older Adult)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers: No

Inclusion Criteria:

-Women with vulvodynia (diagnosed according to the 2015 Consensus Terminology)
-multidisciplinary treatment for at least 3 months
-Informed consent

Exclusion Criteria:

-Current genital infection (i.e. candidiasis, herpes )
-Inflammatory vulvar disease/ dermatosis (i.e. lichen sclerosus, lichen planus)
-Neoplastic vulvar disease (e.g. HSIL Vulva, Paget disease)
-Recent vulvar trauma (i.e. bleeding, erosion or ulceration)
-Pudendal neuralgia
-Pregnancy, delivery <6 months -Epilepsy or major neurologic or psychiatric morbidity -Active systemic infection -Previous treatment with ionizing radiation in the area to be treated -History of wound healing disorders (i.e. hyperpigmentation, abnormal scarring) -Fever -Systemic or local autoimmune disorders -History of photosensitivity disorder

https://clinicaltrials.gov/ct2/show/NCT04711369?cond=vulvodynia&draw=2&rank=1

Acupuncture in a Multidisciplinary Approach for Vulvodynia and Chronic Pelvic Pain (AMALIA)

For more information, please contact: Gerda Trutnovsky, MD by phone +43 316 385 ext 81081 or email trutnovsky@medunigraz.at
OR
Contact Daniela Gold, MD by phone +43 316 385 ext 81437 or email daniela.gold@medunigraz.at

Ages Eligible for Study: 18 Years to 80 Years (Adult, Older Adult)
Sexes Eligible for Study: Female
Accepts Healthy Volunteers: No

Inclusion Criteria:
Women with vulvodynia and/or chronic pelvic pain of at least 6 months duration
multidisciplinary treatment for at least 3 months

Exclusion Criteria:
Pregnancy
Current malignancy
Major neurologic or psychiatric morbidity
Study participation in Lydia trial (Lasertherapy for vulvodynia)

https://clinicaltrials.gov/ct2/show/NCT05324280?cond=vulvodynia&draw=3&rank=20

Somatocognitive Therapy in Treatment of Provoked (Localized) Vestibulodynia – Randomized Clinical Trial (ProLoVe Study) (ProLoVe)

For more information or to participate please contact Slawomir Wojniusz, Phd by phone +47 419 26 564 or emaail slawomir@oslomet.no
OR
Contact Mette B Kaarbø, Msc by phone +47 974 11 669 or email metteboy@oslomet.no

Ages Eligible for Study: 18 Years to 35 Years (Adult)
Sexes Eligible for Study: Female
Gender Based Eligibility: Yes
Accepts Healthy Volunteers: No

Inclusion Criteria:
Clinical diagnosis of provoked vestibulodynia
Age: 18 to 35
Must understand Norwegian well enough to be able to complete questionnaires
Must be able to attend treatment in Oslo, Norway

Exclusion Criteria:
Active infection in the vulvar region
Dermatologic lesion in the vulvar region
Presence of diagnostically confirmed psychiatric condition that necessitate treatment by a medical specialist in psychiatry of clinical psychology

https://clinicaltrials.gov/ct2/show/NCT04613713?cond=vulvodynia&draw=2&rank=49

An Investigation of Nomothetic Versus Idiographic Assessment in Chronic Pain

For more information or to participate, please contact Monica Buhrman, PhD by phone 0046184712126 or email monica.buhrman@psyk.uu.se

Ages Eligible for Study: 18 Years and older (Adult, Older Adult)
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Sampling Method: Non-Probability Sample

Study Population
People reporting diagnoses of endometriosis, vulvodynia, or fibromyalgia.

Inclusion Criteria:
-Age 18 or over
-Reporting diagnoses of endometriosis, vulvodynia, or fibromyalgia
-The pain condition present persistently or recurrently during ≥ 3 months
-Access to an internet-enabled smartphone/tablet
-Fluent in written Swedish

Exclusion criteria:
– Planned surgery during the upcoming 6 weeks

https://clinicaltrials.gov/ct2/show/NCT05518630?cond=vulvodynia&draw=2&rank=54